IntroductionVenetoclax is a BCL-2 inhibitor suitable for those with 17p deficiency through FDA approved testing
Treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one previous treatment.
This indication is approved based on the overall response rate under accelerated approval. Continued approval of this indication may take
Depends on the description and confirmation of clinical benefits in confirmatory trials.
Warning & Precautions- Tumor Lysis Syndrome (TLS): Predicting TLS: Assess risk in all patients. Anti-hyperuric acid
Pre-administration of antihypermic drugs and ensure proper hydration. When the overall risk increases, stronger measures (intravenous hydration,
Frequent surveillance, hospitalization).
- Neutropenia: monitor blood cell count and signs of infection, and treat according to clinically appropriate methods.
- Vaccination: Do not give live attenuated vaccine before, during, or after Venetoclax treatment.
- Embryo-fetal toxicity: may cause embryo-fetal harm. Advise women with reproductive potential At risk, and use effective contraception during treatment.
How to Use- Method of administration
- Venetoclax is initially treated at 20 mg once a day for 7 days, followed by a weekly incremental dose The medication schedule is to the recommended daily dose of 400mg.
- Venetoclax tablets should be taken orally with food and water once a day. Do not chew, crush or break the tablet.
- Prevent tumor lysis syndrome.
- Dosage specifications
- Tablets, 10mg, 50mg, 100mg.
- Contraindications: strong inhibitors of Venetoclax and CYP3A are contraindicated in the initial and increasing dose stages use simultaneously.
Side EffectsThe most common adverse reactions (≥20%) include: neutropenia, diarrhea, nausea, anemia, upper
(Please read this notice carefully and take the medicine according to this notice or under the guidance of a doctor)
Respiratory tract infections, thrombocytopenia, and fatigue.
More Information
Storage
The storage environment is below 30°C (86°F).
Disclaimer:The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.