IntroductionNaivex is an antiviral drug designed to treat HIV-1 infection in adults and children 12 years of age and weighing 40 kg or more as part of combination antiretroviral therapy.?The drug is recommended for use in patients who have not received therapy ("naive"), and in patients with HAART.?In some cases, it can be used in patients with partial resistance to integrase inhibitors.
Warning & PrecautionsTalk to Doctor
Talk to your doctor before you take this medicine, if you:
- Hypersensitivity reactions to dolutegravir (and auxiliary substances).
- Admission of anti-arrhythmic drug Dofetilide (English name Tikosyn)
- Age is less than 12 years and body weight is less than 40 kg
InteractionsTell your doctor if you are taking,
- Co-infection with hepatitis C does not matter for the pharmacokinetics of dolutegravir. Data on co-infection with hepatitis B are limited.
- The simultaneous use of dolutegravir and other drugs that inhibit UDP-HT 1A1, UDF-GT1A3, UDF-GT1A9, CYP3A4 and/or Pgp, may increase the concentration of dolutegravir in blood plasma.
- Contraindicated simultaneous reception with dofetilide.
- The simultaneous use of dolutegravir and etravirine is not recommended unless the patient receives simultaneously atazanavir/ritonavir, lopinavir/ritonavir or darunavir/ritonavir.
- The drug should not be administered together with antacids containing polyvalent cations. It is recommended to use dolutegravir 2 hours before or 6 hours after the application of these agents.
- Dolutegravir may increase the concentrations of metformin. It is necessary to monitor patients during therapy, and metformin dosages may need to be adjusted.
How to Use
Dolutegravir is rapidly absorbed after ingestion. The average time to reach the maximum concentration is 2-3 hours. When you take 1 time per day, the pharmacokinetic steady state is reached approximately 5 days after the beginning of the oral administration. Food increases the degree and reduces the rate of absorption of dolutegravir. These changes are generally clinically insignificant, so Instgra can be taken regardless of food intake. However, patients infected with HIV-1 with a certain resistance to integrase inhibitors are advised to take Naivex with food.
Side EffectsLike all medicines, this medicine can cause side effects, although not everybody gets them
Common
- ?insomnia
- ?a headache.
- dizziness, unusual dreams
- nausea
- diarrhea
- vomiting
- flatulence
- pain in the upper abdomen
- rash
- itching
- fatigue
Uncommon
- pain in the abdomen
- discomfort in the abdomen
- hepatitis
Rare
- a hypersensitivity reaction
- a syndrome of a restoration of immunity
More InformationStorage
- Keep this medicine out of reach of children
- Store at room temperature (15-25°C)
- Do not use this medicine after the expiry date
- Keep the drug in a dry place
Disclaimer:The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.